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EnoGene Biotech Co. Ltd, is a biological high-tech corporation that specializes in developing and production of antibody related products for biochemistry, molecular biology, immunology and other reagents in general laboratory use. EnoGene Biotech possesses advanced equipments, a highly experienced professional team, and the first class laboratory technology to offer the best products and services to universities, colleges, academes and institutes. At the same time, EnoGene Biotech focuses on transferring and developing the innovative research findings to reagent products. We will contribute to the development of biomedical research with our continuous new products.


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SAM68 Regulates Neuronal Activity-Dependent Alternative Splicing of Ne…

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 타이틀

- SAM68 Regulates Neuronal Activity-Dependent Alternative Splicing of Neurexin-1

 저자

- Takatoshi Iijima et al

 게시일

- 23 December 2011

 게시장소

- Volume 147, Issue 7, Pages 1601–1614



Summary

The assembly of synapses and neuronal circuits relies on an array of molecular recognition events and their modification by neuronal activity. Neurexins are a highly polymorphic family of synaptic receptors diversified by extensive alternative splicing. Neurexin variants exhibit distinct isoform-specific biochemical interactions and synapse assembly functions, but the mechanisms governing splice isoform choice are not understood. We demonstrate that Nrxn1 alternative splicing is temporally and spatially controlled in the mouse brain. Neuronal activity triggers a shift in Nrxn1 splice isoform choice via calcium/calmodulin-dependent kinase IV signaling. Activity-dependent alternative splicing of Nrxn1 requires the KH-domain RNA-binding protein SAM68 that associates with RNA response elements in the Nrxn1 pre-mRNA. Our findings uncover SAM68 as a key regulator of dynamic control of Nrxn1 molecular diversity and activity-dependent alternative splicing in the central nervous system.

Graphical Abstract

 

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